SidaGhanaV1, Main, Exploration, bibRecord, 001501

Interethnic variation of drug metabolism

Identifieur interne : 001501 ( Main/Exploration ); précédent : 001500; suivant : 001502

Interethnic variation of drug metabolism

Auteurs : Werner Kalow [Canada]

Source :

Trends in Pharmacological Sciences [ 0165-6147 ] ; 1991.

RBID : ISTEX:38806A0460B1EE2A47BA2845C27E4D87E0C76E96

Descripteurs français

Wicri :
- topic : Enzyme.

English descriptors

KwdEn :
- Alcohol dehydrogenase, Allele frequencies, Antiviral therapy, Average activity, Average enzyme activity, Clinical significance, Codeine, Debrisoquine, Distribution curves, Drug metabolism, Enzyme, Enzyme activity, Enzyme deficiency, Enzyme variants, Esterase activity, Frequency distribution curve, Full enzyme activity, Genetic variants, Heterozygote, Immunorestorative therapy, Interethnic, Metabolism, Multiple allelism, Probe drugs, Such differences, Tips march, Vaccine development, Variant, Viral replication, Western populations.
Teeft :
- Alcohol dehydrogenase, Allele frequencies, Antiviral therapy, Average activity, Average enzyme activity, Clinical significance, Codeine, Debrisoquine, Distribution curves, Drug metabolism, Enzyme, Enzyme activity, Enzyme deficiency, Enzyme variants, Esterase activity, Frequency distribution curve, Full enzyme activity, Genetic variants, Heterozygote, Immunorestorative therapy, Interethnic, Metabolism, Multiple allelism, Probe drugs, Such differences, Tips march, Vaccine development, Variant, Viral replication, Western populations.

Abstract

There are many examples of differences between ethnically defined populations with regard to drug-metabolizing enzymes i.e. enzymes that serve as defences against exogenous chemicals. The prevalence of variants of enzymes such as monooxygenases, dehydrogenases, esterases and some transferases is not uniform, and this leads to differences in metabolism of drugs such as aspirin and diazepam, among others. Werner Kalow explains why the mere counting of a genetic variant may not be sufficient to uncover more major problems such as may be posed by multiple allelism or heterozygosity, and why it may be predicted that a large number of drugs will display interethnic differences in function.

Url:

https://api.istex.fr/document/38806A0460B1EE2A47BA2845C27E4D87E0C76E96/fulltext/pdf

DOI: 10.1016/0165-6147(91)90516-U

Affiliations:

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Le document en format XML

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<term>Average enzyme activity</term>
<term>Clinical significance</term>
<term>Codeine</term>
<term>Debrisoquine</term>
<term>Distribution curves</term>
<term>Drug metabolism</term>
<term>Enzyme</term>
<term>Enzyme activity</term>
<term>Enzyme deficiency</term>
<term>Enzyme variants</term>
<term>Esterase activity</term>
<term>Frequency distribution curve</term>
<term>Full enzyme activity</term>
<term>Genetic variants</term>
<term>Heterozygote</term>
<term>Immunorestorative therapy</term>
<term>Interethnic</term>
<term>Metabolism</term>
<term>Multiple allelism</term>
<term>Probe drugs</term>
<term>Such differences</term>
<term>Tips march</term>
<term>Vaccine development</term>
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<term>Western populations</term>
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<term>Antiviral therapy</term>
<term>Average activity</term>
<term>Average enzyme activity</term>
<term>Clinical significance</term>
<term>Codeine</term>
<term>Debrisoquine</term>
<term>Distribution curves</term>
<term>Drug metabolism</term>
<term>Enzyme</term>
<term>Enzyme activity</term>
<term>Enzyme deficiency</term>
<term>Enzyme variants</term>
<term>Esterase activity</term>
<term>Frequency distribution curve</term>
<term>Full enzyme activity</term>
<term>Genetic variants</term>
<term>Heterozygote</term>
<term>Immunorestorative therapy</term>
<term>Interethnic</term>
<term>Metabolism</term>
<term>Multiple allelism</term>
<term>Probe drugs</term>
<term>Such differences</term>
<term>Tips march</term>
<term>Vaccine development</term>
<term>Variant</term>
<term>Viral replication</term>
<term>Western populations</term>
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<front><div type="abstract" xml:lang="en">There are many examples of differences between ethnically defined populations with regard to drug-metabolizing enzymes i.e. enzymes that serve as defences against exogenous chemicals. The prevalence of variants of enzymes such as monooxygenases, dehydrogenases, esterases and some transferases is not uniform, and this leads to differences in metabolism of drugs such as aspirin and diazepam, among others. Werner Kalow explains why the mere counting of a genetic variant may not be sufficient to uncover more major problems such as may be posed by multiple allelism or heterozygosity, and why it may be predicted that a large number of drugs will display interethnic differences in function.</div>
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Interethnic variation of drug metabolism

Interethnic variation of drug metabolism

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri